METABOLIC ALKALOSIS AS A RISK FACTOR FOR POSTPARTUM PARESIS IN COWS

L K GERUNOVA; L K GERUNOVA

UDC

619

METABOLIC ALKALOSIS AS A RISK FACTOR FOR POSTPARTUM PARESIS IN COWS

Published in Vestnik of Omsk SAU · Pages 140–149 · Rubric: VETERINARY AND ZOOTECHNY

EDN: VZPHVK

Received: 06.12.2024 Accepted: 15.12.2024 Published: 25.12.2024

Authors

L K GERUNOVA

Omsk State Agrarian University named after P.A. Stolypin

L K GERUNOVA

Omsk State Agrarian University named after P.A. Stolypin

ABSTRACT

The development of metabolic alkalosis is due to a number of reasons: an unbalanced diet, including mineral substances, mechanical obstruction of the gastrointestinal tract, distal tubulopathies, congenital chloride diarrhea, hyperaldosteronism, neoplasia, overdose of glucocorticoids. The hypothalamic-pituitary-adrenal system, gastrointestinal tract and kidneys are involved in the pathological process. The purpose of the review is to show the relationship of metabolic alkalosis with the development of postpartum paresis in cows. Databases of the scientific electronic library eLibrary, the National Library of Medicine of the USA (PubMed), the scientific electronic library of Cyber Medicine (cyberlenika.ru ), the Rospatent platform were used for writing the literature review. An analysis of the literature indicates that metabolic alkalosis causes a change in the sensitivity of receptors to PTH, as a result of which the lack of calcium in the body is not compensated by the synthesis of calcitriol and the release of calcium from the bone depot. Metabolic alkalosis is characterized by symptoms such as decreased or loss of appetite, hypotension or atony of the pancreas, sinusitis, putrid odor from the oral cavity, generalized muscle weakness, if the hepatobiliary system is included in the process, an increase in the boundaries of the liver with percussion, soreness, jaundice of the mucous membranes. The pH of blood, saliva, urine, and scar contents changes. In the blood, there is an increase in HCO 3 - against the background of a decrease in K + and Cl - , an increase in the concentration of total protein, an excessive concentration of bases, an increase in reserve alkalinity, and immunological shifts. The quantitative and qualitative composition of infusoria is changing. A pathomorphological examination reveals signs of chronic inflammation. Compensatory reactions are carried out due to cellular mechanisms, extracellular buffer systems, hypoventilation, and renal excretion. The treatment is aimed at restoring the pH to normal values. Prevention of metabolic alkalosis reduces the risk of developing postpartum paresis in cows.

KEYWORDS

metabolic alkalosis, postpartum paresis, hypokalemia, hypomagnesemia, bicarbonates, sodium, calcium

1. Galenovye kompozicii, podhodyaschie dlya vvedeniya zhivotnomu, otlichnomu ot cheloveka, ih primenenie i sootvetstvuyuschie sposoby: pat. 2591080 Ros. Federaciya. № 2013129528/15/ Sheri Lorn, Vayda-Dyubo Zhan-P'er; zayavl. 27.11.2011; opubl. 07.06.2012, Byul. № 1. 39 s.

2. Stoletova V.A., Pristach N.V., Pristach L.N. Kormlenie korov v tranzitnyy period v usloviyah ZAO "Plemhoz im. Tel'mana" // Rol' molodyh uchenyh v reshenii aktual'nyh zadach APK: sb. nauch. tr. Mezhdunar. nauch.-prakt. konf. mol. uchenyh i studentov. 2016. S. 152-158.URL: item.asp?id=29996912 (data obrascheniya: 15.06.2024). EDN: https://elibrary.ru/ZGKZHV

3. Morrison V.V., Chesnokova N.P., Bizenkova M.N. Kislotno-osnovnoe sostoyanie. Tipovye narusheniya kislotno-osnovnogo sostoyaniya // Mezhdunarodnyy zhurnal prikladnyh i fundamental'nyh issledovaniy. 2015. № 3 (chast' 2). S. 273-278 URL: https://applied-research.ru/ru/article/view?id=6530 (data obrascheniya: 16.06.2024). EDN: https://elibrary.ru/TMJTGJ

4. Litvickiy P.F. Narusheniya kislotno-osnovnogo sostoyaniya // VSP. 2011. № 2. URL: https://cyberleninka.ru/article/n/narusheniya-kislotno-osno vnogo-sostoyaniya-1 (data obrascheniya: 04.06.2024). EDN: https://elibrary.ru/NWEHAX

5. Ocenka parametrov kislotno-schelochnogo sostoyaniya u pacientov s meningiomami i gliomami v rannem posleoperacionnom periode / E.S. Orlova [i dr.] // Rossiyskiy neyrohirurgicheskiy zhurnal imeni prof. A.L. Polenova. 2023. T. 15. № 2. S. 21-26. URL: item.asp?id=54122635 (data obrascheniya: 15.06.2024). EDN: https://elibrary.ru/KCSQPY

6. Uspenskaya I.D., Portnova I.N. Vrozhdennaya hloridnaya diareya: opisanie klinicheskogo sluchaya // Medicinskiy al'manah. 2011. № 6 (19). S. 172-173. URL: item.asp?id=17075848 (data obrascheniya: 17.06.2024). EDN: https://elibrary.ru/OJRLHV

7. Ostryy gipokaliemicheskiy paralich vsledstvie peredozirovki preparata, soderzhaschego koren' solodki / N.A. Suponeva [i dr.] // Annaly klinicheskoy i eksperimental'noy nevrologii. 2008. T. 2. № 1. S. 47-51. URL: item.asp?id=15130941 (data obrascheniya: 15.06.2024). EDN: https://elibrary.ru/MTCWMR

8. Nikulina N.B. Immunologicheskie pokazateli krovi korov pri razvitii metabolicheskogo alkaloza // Permskiy agrarnyy vestnik. 2023. № 2 (42). S. 113-119. URL: item.asp?id=54301912 (data obrascheniya: 17.06.2024). EDN: https://elibrary.ru/EZBTLC

9. Nikulina N.B. Izmenenie rubcovoy mikroflory u doynyh korov s alkalozom pri ispol'zovanii kormovoy dobavki "KETOSTOP-EL" // Agrotehnologii XXI veka: strategiya razvitiya, tehnologii i innovacii: materialy Vseros. nauch.-prakt. konf. Ministerstvo nauki i vysshego obrazovaniya Rossiyskoy Federacii. Federal'noe gosudarstvennoe byudzhetnoe obrazovatel'noe uchrezhdenie vysshego obrazovaniya "Permskiy gosudarstvennyy agrarno-tehnologicheskiy universitet imeni akademika D.N. Pryanishnikova". 2022. S. 253-256. URL: item.asp?id=50039103 (data obrascheniya: 16.06.2024). EDN: https://elibrary.ru/MLCJCC

10. Buryakov N.P. Ocenka polnocennosti racionov krupnogo rogatogo skota // Molochnaya promyshlennost'. 2014. № 7. S. 19-24. URL: item.asp?id=21671266 (data obrascheniya: 15.06.2024). EDN: https://elibrary.ru/SGGAWH

11. Nikulina N.B., Aksenova V.M. Prichiny rasprostraneniya zabolevaniy krupnogo rogatogo skota v hozyaystvah Permskogo kraya // Permskiy agrarnyy vestnik. 2019. № 4 (28). S. 113-119. URL: item.asp?id=42638790 (data obrascheniya: 17.06.2024). EDN: https://elibrary.ru/ETUVTY

12. Pereraspredelenie elektrolitov mezhdu eritrocitami i plazmoy krovi korov pri narushenii kislotno-schelochnogo ravnovesiya (acidoz rubca) / G.F. Ryzhkova [i dr.] // Vestnik Kurskoy gosudarstvennoy sel'skohozyaystvennoy akademii. 2018. № 4. S. 136-139. URL: item.asp?id=35017281 (data obrascheniya: 16.07.2024). EDN: https://elibrary.ru/UQKIZM

13. Gluhov D. Effektivnoe ispol'zovanie proteina v racionah dlya korov // Nauchno-prakticheskiy zhurnal dlya rukovoditeley i specialistov APK. 2020. URL: https://zzr.ru/zzr-2020-12-012# (data obrascheniya: 18.06.2024).

14. Kaliysberegayuschie svoystva magniya / Gromova O.A. [i dr.] // Kardiologiya. 2013. T. 53. № 10. S. 38-48. URL: item.asp?id=20862068 (data obrascheniya: 18.06.2024). EDN: https://elibrary.ru/RONQMH

15. Nicpoń J., Hejłasz Z. Zum Einfluss der metabolischen Alkalose auf Kolostrum- und Milchqualität von Kühen sowie auf den Gesundheitszustand ihrer Neugeborenen / Dtsch Tierarztl Wochenschr. 1991. 98(6) URL: https://pubmed.ncbi.nlm.nih.gov/1889361/(data obrascheniya: 18.06.2024).

16. Mihaylov S.G., Lucay V.I. Diagnostika i terapiya pri ileuse u melkih zhivotnyh // Materialy Vseros. nauch.-prakt. konf. "Nedelya studencheskoy nauki". Ministerstvo sel'skogo hozyaystva Rossiyskoy Federacii; Federal'noe gosudarstvennoe byudzhetnoe obrazovatel'noe uchrezhdenie vysshego obrazovaniya "Moskovskaya gosudarstvennaya akademiya veterinarnoy mediciny i biotehnologii - MVA imeni K.I. Skryabina". 2023. S. 196-199. URL: item.asp?id=53949823 (data obrascheniya: 17.06.2024). EDN: https://elibrary.ru/LLSVAU

17. Lambacher B., Wittek T. A suspected case of Addison's disease in cattle / Can Vet J. 2015. 56(9). URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535506/(data obrascheniya: 19.06.2024).

18. Petlevye tubulopatii: sindrom Barttera / A.A. Baranov [i dr.] // Pediatricheskaya farmakologiya. 2019. T. 16. № 2. S. 85-90. URL: item.asp?id=38205256 (data obrascheniya: 19.06.2024). EDN: https://elibrary.ru/TJCPZG

19. Distal'nye tubulopatii. Sindrom Gitel'mana / A.A. Baranov [i dr.] // Pediatricheskaya farmakologiya. 2019. T. 16. № 3. S. 144-148. URL: item.asp?id=39356597 (data obrascheniya: 19.06.2024). EDN: https://elibrary.ru/AIWTWF

20. Distal'nye tubulopatii. Sindrom Liddla / A.A. Baranov [i dr.] // Pediatricheskaya farmakologiya. 2019. T. 16. № 3. S. 149-151. URL: item.asp?id=39356599 (data obrascheniya: 19.06.2024). EDN: https://elibrary.ru/OSLKGV

21. Bogdanov A.R., Derbeneva S.A., Golubeva A.A. Al'dosteron - vozmozhnyy prediktor serdechnoy nedostatochnosti u bol'nyh ozhireniem // Effektivnaya farmakoterapiya. 2014. № 51. S. 18-25. URL: item.asp?id=22941328 (data obrascheniya: 20.06.2024). EDN: https://elibrary.ru/TIAQTR

22. Logatkina A.V., Terehov I.V., Nikiforov V.S. Vzaimosvyaz' vazoaktivnyh i neyroendokrinnyh mehanizmov s sostoyaniem antioksidantnoy zaschity u bol'nyh s arterial'noy gipertenziey // Regionarnoe krovoobraschenie i mikrocirkulyaciya. 2022. T. 21. № 1 (81). S. 36-45. URL: item.asp?id=48235744 (data obrascheniya: 21.06.2024). EDN: https://elibrary.ru/JKTEWB

23. Lenkova N.V. Metabolicheskiy stress u korov pri rodil'nom pareze // Vestnik Ryazanskogo gosudarstvennogo agrotehnologicheskogo universiteta im. P.A. Kostycheva. 2022. T.14, №2. S. 50-56. URL: item.asp?id=49168572 (data obrascheniya: 17. 06. 2024). EDN: https://elibrary.ru/CZUITV

24. Karlovich N.V., Mohort T.V., Volchek Yu.A. Renin - angiotenzin - al'dosteronovaya sistema: tradicionnaya funkciya i pleyotropnye effekty regulyacii fosforno-kal'cievogo metabolizma // Medicinskie novosti. 2021. №10 (325). URL: https://cyberleninka.ru/article/n/renin-angiotenzin-aldosteronovaya-sistema-traditsionnaya-funktsiya-i-pleyotropnye-effekty-regulyatsii-fosforno-kaltsievogo (data obrascheniya: 19.06.2024).

25. Pervichnaya nadpochechnikovaya nedostatochnost' / T.N. Markelova [i dr.] // Zdravoohranenie Chuvashii. 2023. № 1. S. 36-51. URL: item.asp?id=50425562 (data obrascheniya: 20.06.2024). EDN: https://elibrary.ru/SACGFP

26. Lapshina A.M., Marova E.I. Ocenka biologicheskogo povedeniya AKTG-sekretiruyuschih opuholey gipofiza pri pomoschi razlichnyh metodov // Voprosy neyrohirurgii im. N.N. Burdenko. 2015. T. 79. № 6. S. 107-114. URL: item.asp?id=25303035 (data obrascheniya: 19.06.2024). EDN: https://elibrary.ru/VHSJGN

27. Vrozhdennaya disfunkcii kory nadpochechnikov (obzor literatury i opisanie klinicheskogo sluchaya) / R.I. Arakelyan [i dr.] // Vestnik molodogo uchenogo. 2017. № 1 (16). S. 42-48. URL: item.asp?id=29094470 (data obrascheniya: 21.06.2024). EDN: https://elibrary.ru/YMRNOT

28. Management of endocrine disease: Cushing's syndrome due to ectopic ACTH secretion: an expert operational opinion / Young J. [et al.] // Eur J Endocrinol. 2020. 182(4). URL: https://pubmed.ncbi.nlm.nih.gov/31999619 (data obrascheniya: 21.06.2024).

29. Arhipov A.V. O nekotoryh aktual'nyh aspektah mineral'nogo pitaniya zhivotnyh // Veterinariya, zootehniya i biotehnologiya. 2015. № 3. S. 38-48. URL: download/elibrary_23205131_74538857.htm (data obrascheniya: 18.06.2024). EDN: https://elibrary.ru/TNUTEJ

30. McGuirk S.M, Butler D.G. Metabolic alkalosis with paradoxic aciduria in cattle // J Am Vet Med Assoc. 1980. 177(6). URL: https://pubmed.ncbi.nlm.nih.gov/7440350 (data obrascheniya: 22.06.2024).

31. Evaluation of abomasal outflow diversion as an experimental model of hypochloremic, hypokalemic metabolic alkalosis in lactating cows / Ward J.L., Smith D.F., Fubini S.L. [et al] // Can J Vet Res. 1994. 58(1). URL: https://pubmed.ncbi.nlm.nih.gov/8143247 (data obrascheniya: 22.06.2024).

32. Nikulina N.B., Baydak E.V. Morfologicheskie izmeneniya stenki rubca u korov s alkalozom // Agrotehnologii XXI veka: strategiya razvitiya, tehnologii i innovacii. Materialy Vseros. nauch.-prakt. konf., posvyasch. desyatiletiyu nauki i tehnologiy v Rossiyskoy Federacii. Perm', 2023. S. 219-222. URL: item.asp?id=54939665 (data obrascheniya: 21.06.2024). EDN: https://elibrary.ru/WQXLFM

33. Pogrel'chuk I.O., Ivanova S.N. Alkaloz krupnogo rogatogo skota i vliyanie na reproduktivnuyu funkciyu // Veterinarnye i biologicheskie nauki. 2019. T. V, Ch. 2. S. 71-73. URL: http://lib.ugsha.ru:8080/handle/123456789/22231 (data obrascheniya: 20.06.2024).

34. Roussel AJ. Fluid therapy in mature cattle // Vet Clin North Am Food Anim Pract. 2014. 30(2). URL: https://pubmed.ncbi.nlm.nih.gov/24980730/(data obrascheniya: 22.06.2024).

35. Martin W.J., Matzke G.R. Treating severe metabolic alkalosis // Clin Pharm. 1982. 1(1). URL: https://translated.turbopages.org/proxy_u/en-ru.ru.4088eba 1-66d70258-a3b66f93-74722d776562/https/pubmed.ncbi. nlm.nih.gov/6764161/(data obrascheniya: 22.06.2024).

36. Karpov L.M., Protunkevich M.S., Pahomova V.A. Primenenie kompleksa vitaminov "Undevit" i mineral'nogo preparata "Namacit" dlya integral'noy korrekcii metabolicheskogo acidoza i alkaloza // Visnik ONU. Ser. Biologiya. 2013. T. 18, Vip. 3(32). URL: https://elibrary.ru/item.asp?id=24146521 (data obrascheniya: 23.06.2024).

37. Rusakov R. Kislye soli: osobennosti rascheta velichiny kationno-anionnogo balansa raciona // Molochnaya ferma. 2019. URL: https://molochnaya_ferma.rf/kislye-soli-osobennosti-raschyota-velichiny-kationno-anionnogo-b (data obrascheniya: 23.06.2024).

38. Rybolovskaya V.V., Moshkina S.V. Preduprezhdenie rodovogo pareza molochnogo skota // Aktual'nye voprosy i puti ih resheniya v veterinarnoy medicine i zhivotnovodstve: sb. materialov Mezhdunar. nauch.-prakt. konf., posvyasch. 90-letiyu so dnya rozhdeniya professora Yu.F. Yudicheva. Tyumen', 2021. S. 277-281. URL: item.asp?id=46509351 (data obrascheniya: 23.06.2024). EDN: https://elibrary.ru/YDNOSH

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Oksana Shumakova

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GERUNOVA L. K., GERUNOVA L. K. METABOLIC ALKALOSIS AS A RISK FACTOR FOR POSTPARTUM PARESIS IN COWS // . 2024. pp. 140-149. EDN: VZPHVK. (Date of access 20.08.2026).

MLA

L K GERUNOVA, GERUNOVA L. K.. "METABOLIC ALKALOSIS AS A RISK FACTOR FOR POSTPARTUM PARESIS IN COWS." (2024): 140-149. EDN: VZPHVK.

APA

GERUNOVA L. K., GERUNOVA L. K. (2024). METABOLIC ALKALOSIS AS A RISK FACTOR FOR POSTPARTUM PARESIS IN COWS. , 140-149. EDN: VZPHVK.

Chicago

L K GERUNOVA, GERUNOVA L. K.. "METABOLIC ALKALOSIS AS A RISK FACTOR FOR POSTPARTUM PARESIS IN COWS." , no. (2024): 140-149. EDN: VZPHVK.

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{{cite journal | author = GERUNOVA L. K., GERUNOVA L. K. | title = METABOLIC ALKALOSIS AS A RISK FACTOR FOR POSTPARTUM PARESIS IN COWS | journal = | year = 2024 | pages = 140-149 }} EDN: VZPHVK

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