Vestnik of Omsk SAU Vestnik of Omsk SAU ВЕСТНИК ОМСКОГО ГОСУДАРСТВЕННОГО АГРАРНОГО УНИВЕРСИТЕТА 2222-0364 132113 URJHEG ВЕТЕРИНАРИЯ И ЗООТЕХНИЯ VETERINARY AND ZOOTECHNY ВЕТЕРИНАРИЯ И ЗООТЕХНИЯ THE EFFECT OF INTESTINAL MICROFLORA RESISTANT TO ANTIBIOTICS AND DRUGS ON THE SOIL MICROBIOME ВЛИЯНИЕ КИШЕЧНОЙ МИКРОФЛОРЫ, РЕЗИСТЕНТНОЙ К АНТИБИОТИКАМ, И ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ НА ПОЧВЕННЫЙ МИКРОБИОМ КОЛЕНЧУКОВА О А KOLENCHUKOVA O A КОЛОМЕЙЦЕВ А В KOLOMEITSEV A V СТУПИНА А Н KRAVCHUK V YU КРАВЧУК В Ю MAKAROV A V МАКАРОВ А В KHANIPOVA V A ХАНИПОВА В А ZEMLYANSKIY R D ЗЕМЛЯНСКИЙ Р Д TIMOFEEVA A S ТИМОФЕЕВА А С OVSYANKINA S V ОВСЯНКИНА С В ABOLENTSEVA P A АБОЛЕНЦЕВА П А ABOLENTSEVA P A Красноярский государственный аграрный университет ru Krasnoyarsk State Agrarian University ru Красноярский государственный аграрный университет ru Krasnoyarsk State Agrarian University ru Сибирский федеральный университет ru Siberian Federal University ru Красноярский государственный аграрный университет ru Krasnoyarsk State Agrarian University ru Красноярский государственный аграрный университет ru Krasnoyarsk State Agrarian University ru Красноярский государственный аграрный университет ru Krasnoyarsk State Agrarian University ru Красноярский государственный аграрный университет ru Krasnoyarsk State Agrarian University ru Красноярский государственный аграрный университет ru Krasnoyarsk State Agrarian University ru Красноярский государственный аграрный университет ru Krasnoyarsk State Agrarian University ru Красноярский государственный аграрный университет ru Krasnoyarsk State Agrarian University ru 25 09 2024 25 09 2024 55 3 87 97 06 09 2024 15 09 2024 https://vestnik.omgau.ru/en/nauka/article/132113/view

Цель статьи - изучение современного состояния проблемы влияния кишечной микрофлоры, резистентной к антибиотикам, и лекарственных препаратов, содержащихся в навозе обычных животноводческих ферм, на микробиом почвы, и распространения генов устойчивости к противомикробным препаратам (ARGs) в окружающей среде. Коллективом авторов проведен анализ 123 источников, опубликованных в период с 2000 г. по июнь 2024 г., 52 из них использованы при подготовке обзора. Анализ научной литературы показал существование очень разнообразных и отчетливо отличающихся сообществ микроорганизмов, содержащихся в свежих фекалиях и навозе. Обнаружено, что виды и резистентные бактерии кишечной микрофлоры человека и животных значительно увеличивались во время накопления фекалий. Учеными отмечено, что при использовании навоза в сельском хозяйстве ветеринарные препараты и биоциды попадают в окружающую среду, влияя на качество почвы и воды. В зависимости от граничных условий, таких как температура хранения, содержание сухого вещества, кормление животных и доступность акцепторов электронов, фармацевтические препараты и биоциды могут подвергаться дальнейшей трансформации. Таким образом, анализ научной литературы показал, что это одна из наиболее сложных тем с пробелами в знаниях, связанных с составом, развитием, распространением устойчивости или адаптацией и активностью микробного сообщества. В результате изучения обобщенных мониторинговых исследований можно сделать вывод: ветеринарные лекарственные препараты встречаются в навозе повсеместно. Концентрации сульфадиазина и хлортетрациклина в окружающей среде превышали прогнозируемые концентрации. Такие мониторинговые исследования весьма актуальны с точки зрения оценки экологического риска пищевой безопасности.

The purpose of the article was to study the current state of the problem of the influence of intestinal microflora resistant to antibiotics and drugs contained in manure from conventional livestock farms on the soil microbiome and the spread of ARGs in the environment. Search engines such as "Google Scholar", "Web of Science" and "Pubmed" were used to form the presented review article. The most relevant keywords presented in the article were used for logical search. The team of authors analyzed 123 sources published since 2000 until June 2024, 52 of them were used in preparing the review. In addition, cross-references to the found publications were evaluated. An analysis of the scientific literature has shown very diverse and distinctly different bacterial communities contained in fresh feces and manure. It was found that the species and resistant bacteria of the intestinal microflora of humans and animals increased significantly during the accumulation of feces. Scientists have noted that when using manure in agriculture, veterinary drugs and biocides enter the environment and, consequently, affect the quality of soil and water. Depending on boundary conditions such as storage temperature, dry matter content, animal feeding, and availability of electron acceptors, pharmaceuticals and biocides may undergo further transformation. Thus, an analysis of the scientific literature has shown that this is one of the most difficult topics in which there are gaps in knowledge related to the composition, development or spread of resistance, or adaptation and activity of the microbial community. As a result of the study of generalized monitoring studies, it can be concluded that veterinary medicines are found everywhere in manure. The concentrations of sulfadiazine and chlortetracycline in the environment exceeded the predicted concentrations. At the same time, such monitoring studies are very relevant from the point of view of environmental risk assessment.

 навоз кишечный микробиом почвенный микробиом антибиотики резистентность the purpose of the article was to study the current state of the problem of the influence of intestinal microflora resistant to antibiotics and drugs contained in manure from conventional livestock farms on the soil microbiome and the spread of args in the environment. search engines such as "google scholar" "web of science" and "pubmed" were used to form the presented review article. the most relevant keywords presented in the article were used for logical search. the team of authors analyzed 123 sources published since 2000 until june 2024 52 of them were used in preparing the review. in addition cross-references to the found publications were evaluated. an analysis of the scientific literature has shown very diverse and distinctly different bacterial communities contained in fresh feces and manure. it was found that the species and resistant bacteria of the intestinal microflora of humans and animals increased significantly during the accumulation of feces

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