The tense environmental situation in the world contributes to the contamination of animal feed, food raw materials and food products with ecotoxicants of natural and man-made origin (mycotoxins, toxic elements, pesticides, etc.). To protect animals from the negative effects of toxic substances, enterosorbents of various origins are widely used. Sorbents bind to the toxin in the digestive tract of the animal, after which they are transported through the gastrointestinal tract and excreted from the body. The results of a study of the morpho-biochemical status of the blood of white rats during experimental poisoning with mycotoxins (T-2 toxin and deoxynivalenol), cadmium and diquat against the background of the use of a modified sorbent are shown. The modified sorbent contains zinc-activated bentonite from the Biklyanskoye deposit and polysaccharides of soil bacteria Paenibacillus spp. For the experiment, 4 groups of animals (n = 10) were formed. The first group of animals (biological control) received the basic diet, the second group (toxic control) was given a diet with a mixture of studied ecotoxicants. The third group received a toxic diet with a modified sorbent in the amount of 0.5% of the diet, and the fourth group received the main diet and a modified sorbent in the amount of 0.5% of the diet. The experiment lasted 45 days. According to the results of the study, it was revealed that feeding the modified sorbent against the background of combined poisoning of animals with T-2 toxin, deoxynivalene, cadmium and diquat has a positive effect on morphological and biochemical blood parameters, activates metabolic processes in the animal body.
t-2 toxin, deoxynivalenol, cadmium, diquat, modified sorbent, white rats, blood counts
1. Baskova E.Yu. Primenenie enterosorbentov na osnove nanotehnologiy dlya bor'by s mikotoksikozami zhivotnyh // Uchenye zapiski Kazanskoy gosudarstvennoy akademii veterinarnoy mediciny im. N.E. Baumana. 2008. № 192. S. 234-240. EDN: https://elibrary.ru/CNIKUY
2. Mishina N.N., Semenov E.I., Papunidi K.H. i dr. Obosnovanie vvedeniya v racion zhivotnyh kombinacii sorbentov neorganicheskoy i organicheskoy prirody pri T-2 toksikoze // Veterinarnyy vrach. 2019. № 2. S. 30-37. EDN: https://elibrary.ru/ZCJCTJ
3. Semenov E.I., Tremasova A.M., Matrosova L.E. i dr. Sluchai massovogo otravleniya zhivotnyh, ptic i ryb v nekotoryh regionah Rossiyskoy Federacii i stran SNG // Veterinariya. 2021. № 8. S. 39-44. EDN: https://elibrary.ru/HXKOQS
4. Tarasova E.Yu. Izuchenie sorbcionnoy aktivnosti nanotrubok galluazita po otnosheniyu k zearalenonu i ohratoksinu A // Vestnik Mariyskogo gosudarstvennogo universiteta. Seriya: Sel'skohozyaystvennye nauki. Ekonomicheskie nauki. 2021. № 1(25). S. 64-70. EDN: https://elibrary.ru/CYDCPR
5. Mishina N.N., Aleev D.V., Yamalova G.R., Halikova K.F. Harakteristika in vitro prirodnyh sorbentov k pesticidu klassa neonikotinoidov // Veterinarnyy vrach. 2023. № 3. S. 4-9. EDN: https://elibrary.ru/HGAOFS
6. Gerunova L.K., Gerunov T.V., Shitikov V.V., Gonohova M.N., Gerunov V.I., Kryuchek Ya.O., Tarasenko A.A. Mikotoksiny i eprinomektin: potencial'nye riski pri sochetannom deystvii na organizm zhivotnyh // Vestnik Omskogo gosudarstvennogo agrarnogo universiteta. 2023. № 1(49). S. 84-92. EDN: https://elibrary.ru/NBUIKN
7. Gerunov T.V., Gerunova L.K., Tarasenko A.A., Lapuhova V.A. Sekvestranty mikotoksinov: izbiratel'nost' deystviya i pobochnye effekty // Vestnik Omskogo gosudarstvennogo agrarnogo universiteta. 2022. № 2(46). S. 79-84. EDN: https://elibrary.ru/FDZYRG
8. Gerunov T.V., Gerunova L.K., Simonova I.A., Kryuchek Ya.O. Sochetannoe porazhenie kormov mikotoksinami kak faktor riska mnozhestvennoy patologii zhivotnyh // Vestnik Omskogo gosudarstvennogo agrarnogo universiteta. 2022. № 4(48). S. 116-123. EDN: https://elibrary.ru/SEWUZU
9. Semenenko M.P., Tyapkina E.V., Kuz'minova E.V., Koschaev A. G. Osobennosti proyavleniya hronicheskogo kormovogo mikotoksikoza u laboratornyh krys v usloviyah eksperimenta // Sel'skohozyaystvennaya biologiya. 2019. T. 54. № 4. S. 777-786. EDN: https://elibrary.ru/QBYIVZ
10. Ivanov A.V., Tremasov M.Ya., Ahmetov F.G. i dr. Sochetannoe vozdeystvie fizicheskih i himicheskih faktorov na klinicheskie i biohimicheskie pokazateli zhivotnyh // Veterinarnyy vrach. 2007. № 4. S. 4-6. EDN: https://elibrary.ru/JWAXJB
11. Semenov E.I., Tremasov M.Y., Matrosova L.E. et al. Joint effect of the mycotoxins T-2 toxin, deoxynivalenol and zearalenone on the weaner pigs against a background of the infection load. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2016;1:1860-1868. EDN: https://elibrary.ru/WPDMKR
12. Sadykova A.Sh., Tarasova E.Yu., Matrosova L.E., Semenov E.I., Kanarskaya Z.A., Valiev A.R. Izuchenie sorbcionnoy aktivnosti biosorbentov po otnosheniyu k T-2 toksinu // Veterinarnyy vrach. 2021. № 3. S. 45-52. EDN: https://elibrary.ru/TPTQVM
13. Gorbatova K.K., Gun'kova P.I. Himiya i fizika moloka: uchebnik. Sankt-Peterburg: GIORD, 2012. 336 s. EDN: https://elibrary.ru/SDTQOJ
14. Kur'yanova N.H. Postoronnie himicheskie veschestva v moloke // Nauka v sovremennyh usloviyah: ot idei do vnedreniya. 2014. № 1. S. 331-336. EDN: https://elibrary.ru/SXZDKZ
15. Galyautdinova G.G., Egorov V.I. Toksikologicheskaya ocenka sochetannogo vozdeystviya decisa, T-2 toksina i kadmiya na organizm telyat na urovne PDK // Veterinarnaya medicina. 2013. № 97. S. 418-419. EDN: https://elibrary.ru/STHQVN



