Uveitis is a common disease in small pets. Treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) is not a reliable protection against complications, as extreme conditions significantly destabilize the antioxidant system, leading to an increased need for adenosine triphosphate (ATP). Therefore, the aim was to evaluate the effect of Cytochrome C on antioxidant status and its efficacy in experimentally induced uveitis in laboratory animals. Thirty albino female rats were used in the experiment, divided into three groups of 10 animals each. The uveitis model was simulated in all rats using normal horse serum, administered intravitreally after preliminary sensitization. Control animals were untreated, while the first and second experimental groups received topical and systemic NSAID therapy. Animals in the second experimental group were additionally given 5 mg of Cytochrome C orally once a day for 10 days. After administration of horse serum, photophobia, blepharospasm, decreased intraocular pressure, iris swelling, and miosis were observed. After 10 days, untreated animals showed decreased red blood cell and hemoglobin counts, increased hematocrit, aspartate aminotransferase and creatinine levels, and a significant trend toward increased superoxide dismutase activity. The study results demonstrate the effectiveness of anti-inflammatory therapy. The addition of Cytochrome C to the treatment regimen improved the clinical picture of the disease and prevented the development of complications. An increase in red blood cell counts and hemoglobin concentrations in the blood was observed, while the white blood cell count decreased. Changes in the overall antioxidant status of the animals' blood serum indicated a mitigation of oxidative stress.
cytochrome c, antioxidant status, superoxide dismutase, glutathione peroxidase, rats, uveitis
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