Broiler poultry farming is a rapidly developing and significant area of the poultry industry, driven by its unique characteristics, particularly the rapid growth of chickens and the ability to produce products quickly and with virtually no downtime. Weight gain and feed conversion play a key role in raising meat-producing poultry, as feed efficiency and weight gain determine the economic viability of production. Broiler chickens possess genetic potential for rapid muscle gain. Realizing this genetic potential for high production performance increases the bird's sensitivity to various stress factors that weaken the immune system, including those manifested by an imbalance in the intestinal microflora, which is known to play a key role in the absorption of many nutrients in feed, the development of immunity, and the protection of the intestinal mucosa from colonization by pathogenic and opportunistic microorganisms. In addition to vaccination, preventive and therapeutic antibiotic use is also the basis of treatment and prophylactic regimens in poultry production. Since poultry can be susceptible to a wide range of pathogenic and opportunistic microorganisms during their growth and development, a significant number of antibiotics and antimicrobials from various groups are used for prophylaxis. Rotating medications can also be difficult due to the limited range of medications available on the market today. Prophylactic antibiotic use during poultry rearing does not always provide significant results due to the development of antibiotic resistance in pathogenic microflora, necessitating the search for alternative options for protecting the intestinal flora.
intestinal microbiota, probiotics, synbiotics, broiler chickens
1. Burdashkina V.N., Dar'in A.I. Produktivnost' cyplyat-broylerov krossa "Ross-308" v usloviyah promyshlennoy tehnologii // Niva Povolzh'ya. 2018. № 3. S. 90-94. EDN: https://elibrary.ru/XYMLTV
2. Grozina A.A. Sostav mikroflory zheludochno-kishechnogo trakta u cyplyat-broylerov pri vozdeystvii probiotika i antibiotika (po dannym t-rflp-rt-pcr) // Sel'skohozyaystvennaya biologiya. 2014. № 6. S. 46-58. EDN: https://elibrary.ru/TEPGCX
3. The impact of gut microbial signals on hematopoietic stem cells and the bone marrow microenvironment / Liu X., Zhang H., Shi G. [et al.] // Front. Immunol. 2024. № 15. P. 1-14. DOI:https://doi.org/10.3389/fimmu.2024.1338178 EDN: https://elibrary.ru/VNMFGI
4. Nozdrin G.A., Ivanova A.B., Shevchenko A.I., Nozdrin A.G. Nauchnye osnovy primeneniya probiotikov v pticevodstve: monografiya. Novosibirsk: Izd-vo Novosib. gos. agr. un-ta, 2005. S. 222.
5. Enterococcus isolated from poultry intestine for potential probiotic use / E. Carvajal, S. Contreras, W. Díaz [et al.] // Veterinary World. 2023. Aug;16(8). P.1605-1614. 10.14202/ vetworld.2023.1605-1614. DOI:https://doi.org/10.14202/vetworld.2023.1605-1614 EDN: https://elibrary.ru/PHGETI
6. Different Bacteroides Species Colonise Human and Chicken Intestinal Tract / M. Faldynova, J. Matiasovicova, E. Jahodarova [et al.] // Microorganisms. 2020. Sep 27;8(10). P.1483. DOI:https://doi.org/10.3390/microorganisms8101483 EDN: https://elibrary.ru/SBDHTJ
7. Lundberg R., Scharch C., Sandvang D. The link between broiler flock heterogeneity and cecal microbiome composition // Animal Microbiome. 2021. P. 14 tps://. DOI:https://doi.org/10.1186/s42523-021-00110-7 EDN: https://elibrary.ru/SSQFQO
8. Huynh U., Zastrow M. L. Metallobiology of Lactobacillaceae in the gut microbiome // Journal of Inorganic Biochemistry. 2023. 10.1016/ j.jinorgbio.2022.112023. DOI:https://doi.org/10.1016/j.jinorgbio.2022.112023 EDN: https://elibrary.ru/YXRBTM
9. Linkage between the intestinal microbiota and residual feed intake in broiler chickens / J. Liu, S.N. Stewart, K. Robinson [et al.] // Journal of Animal Science and Biotechnology. 2021. 12(1). P. 22. DOI:https://doi.org/10.1186/s40104-020-00542-2 EDN: https://elibrary.ru/NVUYIP
10. Diaz Carrasco J.M., Casanova N.A., Fernández Miyakawa M.E. Microbiota, gut health and chicken productivity: What is the connection? // Microorganisms. 2019. № 7(10). P. 374. DOI:https://doi.org/10.3390/microorganisms7100374
11. Anaerobic flora, Selenomonas ruminis sp. nov., and the bacteriocinogenic Ligilactobacillus salivarius strain MP3 from crossbred-lactating goats / P. Tanasupawat, S. Chanpongsang, S. Kingkaew [et al.] // Scientific Reports. 2024. 14 P. 4838. DOI:https://doi.org/10.1038/s41598-024-54686-6 EDN: https://elibrary.ru/HDSZFG
12. Anaerobic flora, Selenomonas ruminis sp. nov., and the bacteriocinogenic Ligilactobacillus salivarius strain MP3 from crossbred-lactating goats / S. Poothong, S. Tanasupawat, S. Chanpongsang [et al.] // Scientific Reports. 2024. 14 P. 4838. DOI:https://doi.org/10.1038/s41598-024-54686-6 EDN: https://elibrary.ru/HDSZFG
13. Bacillus subtilis M6 improves intestinal barrier, antioxidant capacity and gut microbial composition in AA broiler / L. Ji, L. Zhang, J. Shen [et al.] // Frontiers in Nutrition. Front. 2022.Volume 9. DOI:https://doi.org/10.3389/fnut.2022.965310
14. Epimahova E.E., Rastovarov E.I., Samokish N.V. Vliyanie probiotikov na balans pitatel'nyh veschestv cyplyat-broylerov // Sel'skohozyaystvennyy zhurnal. 2021. №3 (14). S. 63-69. URL: https://cyberleninka.ru/article/n/vliyanie-probiotikov-na-balans-pitatelnyh-veschestv-tsyplyatbroylerov. EDN: https://elibrary.ru/BYTYBS
15. Vliyanie probiotikov na produktivnost' cyplyat-broylerov / G.M. Topuriya, L.Yu. Topuriya, E.V. Grigor'eva [i dr.] // Izvestiya OGAU. 2014. № 2. S. 143-145. URL: https://cyberleninka.ru/article/n/vliyanie-probiotikov-na-produktivnost-tsyplyatbroylerov (data obrascheniya: 05.03.2025). EDN: https://elibrary.ru/SFSCTR
16. Portyanko A.V., Lysko S.B. Vozbuditeli kishechnyh infekciy cyplyat-broylerov i ih rezistentnost' k antibiotikam // Uchenye zapiski KGAVM im. N.E. Baumana. 2018. №2. S. 156-161. URL: https://cyberleninka.ru/article/n/vozbuditeli-kishechnyhinfektsiy-tsyplyat-broylerov-i-ih-rezistentnost-k-antibiotikam (data obrascheniya: 19.03.2025). EDN: https://elibrary.ru/XQJSIH
17. Funkcii kishechnoy mikroflory organizma v norme i pri patologii / O.S. Molozhavaya, T.V. Ivahnyuk, A.N. Makarenko [i dr.] // Aktual'ni problemi suchasnoї medicini: Visnik ukraїns'koї medichnoї stomatologichnoї akademiї. 2016. №4-1 (56). URL: https://cyberleninka.ru/article/n/funktsii-kishechnoy-mikroflory-organizma-v-norme-i-pri-patologii (data obrascheniya: 19.03.2025). EDN: https://elibrary.ru/WNCJRB
18. Mohammed A.A., Jiang, S., Jacobs, J.A., & Cheng, H.W. Effect of a synbiotic supplement on cecal microbial ecology, antioxidant status, and immune response of broiler chickens reared under heat stress // Poultry Science. 2019. 98(10). P. 4408-4415. DOI:https://doi.org/10.3382/ps/pez246
19. Shehata A.A., Tellez-Isaias, G., & Eisenreich, W. Alternatives to Antibiotics against Pathogens in Poultry // Springer. 2024. p. 43 - 52. ISBN: 978-3-031-70480-2
20. Epidemiology and antimicrobial resistance of Escherichia coli in broiler chickens, farmworkers, and farm sewage in Bangladesh / A.K. Mandal, S. Talukder, M.M. Hasan [et al.] // Vet Med Sci. 2022. p. 187-199.
21. Shaji S., Selvaraj R.K., Shanmugasundaram R. Salmonella Infection in Poultry: A Review on the Pathogen and Control Strategies // Microorganisms. 2023. 11(11), 2814;. DOI:https://doi.org/10.3390/microorganisms11112814 EDN: https://elibrary.ru/UBOBSU
22. Gimah M., & Oluwasemilore, J. Prevalence of Campylobacter in different poultry species. 2025. 16 s. https://www.researchgate.net/publication/389484304.
23. Prevalence and determination of species distribution of Eimeria in poultry from the Swabi district Pakistan Begum / N. Shams, S. Badshah, F. Khattak [et al.] // Veterinary World. 2024. 17(9). P. 1983-1989. DOI:https://doi.org/10.14202/vetworld.2024.1983-1989 EDN: https://elibrary.ru/CQWYEE
24. Strategies for Decontamination and Alleviation of Mycotoxins for Sustainable Poultry Farming - A Review / Y. Attia, T. Ebeid, M. Shafi, N. Zabermawi [et al.] // Annals of Animal Science. 2025. 25(1)/ P. 139-157. DOI:https://doi.org/10.2478/aoas-2024-0089 EDN: https://elibrary.ru/MBKDBX
25. Golubchikova O.A., Rudychev S.A. Al'ternativa primeneniya vtorogo antibiotika s vodoy v sheme lechebnyh meropriyatiy u cyplyat-broylerov. Prakticheskiy opyt // Pticevodstvo. 2023. № 2. S. 65-68. EDN: https://elibrary.ru/LXJASE
26. Shackih E.V., Korol'kova-Subbotkina D.E., Galiev D.M. Sinbioticheskie dobavki v kormlenii cyplyat-broylerov // Pticevodstvo. 2021. № 5. S. 25-28. EDN: https://elibrary.ru/NCIBFD
27. Kridtayopas C., Rakangtong C., Bunchasak C., Loongyai, W. Effect of prebiotic and synbiotic supplementation in diet on growth performance, small intestinal morphology, stress, and bacterial population under high stocking density condition of broiler chickens // Poultry Science, 98(10). 2019. p. 4595-4605. EDN: https://elibrary.ru/OVNJPM
